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Takeyori Saheki Selected Research

Glycerolphosphate Dehydrogenase (Glycerol 3 Phosphate Dehydrogenase)

9/2015Mechanism for increased hepatic glycerol synthesis in the citrin/mitochondrial glycerol-3-phosphate dehydrogenase double-knockout mouse: Urine glycerol and glycerol 3-phosphate as potential diagnostic markers of human citrin deficiency.
11/2012Effects of supplementation on food intake, body weight and hepatic metabolites in the citrin/mitochondrial glycerol-3-phosphate dehydrogenase double-knockout mouse model of human citrin deficiency.
12/2011Metabolomic analysis reveals hepatic metabolite perturbations in citrin/mitochondrial glycerol-3-phosphate dehydrogenase double-knockout mice, a model of human citrin deficiency.
8/2007Citrin/mitochondrial glycerol-3-phosphate dehydrogenase double knock-out mice recapitulate features of human citrin deficiency.

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Takeyori Saheki Research Topics

Disease

31Citrullinemia
08/2013 - 01/2002
27Adult-onset citrullinemia type 2
01/2020 - 01/2002
24Neonatal-onset citrullinemia type 2
04/2016 - 01/2002
13Hyperammonemia
01/2020 - 12/2002
10Fatty Liver
03/2011 - 09/2002
9Intrahepatic Cholestasis
11/2012 - 05/2003
5Brain Diseases (Brain Disorder)
11/2010 - 03/2005
5Cholestasis
04/2010 - 03/2005
4Cardiomegaly (Heart Hypertrophy)
03/2011 - 09/2002
4Neonatal hemochromatosis
01/2005 - 01/2002
3Liver Diseases (Liver Disease)
04/2010 - 02/2006
3Galactosemias (Galactosemia)
08/2009 - 10/2005
3Hypoglycemia (Reactive Hypoglycemia)
08/2007 - 12/2002
3Jaundice (Icterus)
04/2006 - 11/2002
2Body Weight (Weight, Body)
11/2012 - 02/2002
2Hepatic Encephalopathy
01/2010 - 04/2004
2Hepatitis
08/2009 - 01/2008
2Brain Edema (Cerebral Edema)
02/2006 - 03/2005
2Hypoproteinemia
10/2005 - 11/2004
2Coma (Comas)
10/2005 - 01/2002
1Liver Neoplasms (Liver Cancer)
11/2010
1End Stage Liver Disease
01/2010
1Glycogen Storage Disease Type I
08/2009
1Biliary Atresia
08/2009
1Metabolic Diseases (Metabolic Disease)
08/2009
1Polyps
08/2009
1Congenital Syphilis (Hutchinson's Teeth)
08/2009
1Caroli Disease (Caroli's Disease)
08/2009
1Tyrosinemias (Tyrosinemia)
08/2009
1Hypercholesterolemia
05/2009

Drug/Important Bio-Agent (IBA)

33citrinIBA
01/2020 - 01/2002
14aspartate-glutamate carrierIBA
12/2019 - 01/2002
11Urea (Carbamide)FDA LinkGeneric
11/2010 - 12/2002
10CitrullineIBA
04/2016 - 01/2002
9DNA (Deoxyribonucleic Acid)IBA
01/2013 - 01/2002
8CarbohydratesIBA
01/2020 - 05/2003
8Carnitine (L-Carnitine)FDA LinkGeneric
03/2011 - 09/2002
7Proteins (Proteins, Gene)FDA Link
11/2012 - 05/2003
6Glycerol (Glycerine)FDA LinkGeneric
01/2017 - 01/2002
6Pyruvic Acid (Pyruvate)IBA
08/2013 - 08/2007
6AmmoniaIBA
11/2010 - 01/2002
6EnzymesIBA
12/2007 - 12/2002
6Argininosuccinate Synthase (Argininosuccinate Synthetase)IBA
10/2005 - 12/2002
5Protein Isoforms (Isoforms)IBA
09/2015 - 01/2002
5SodiumIBA
08/2013 - 01/2010
5Methionine (L-Methionine)FDA Link
12/2007 - 05/2003
4Aspartic Acid (Aspartate)FDA Link
12/2019 - 01/2002
4Messenger RNA (mRNA)IBA
01/2019 - 09/2002
4Glycerolphosphate Dehydrogenase (Glycerol 3 Phosphate Dehydrogenase)IBA
09/2015 - 08/2007
4Amino AcidsFDA Link
11/2012 - 10/2002
4Bile Acids and Salts (Bile Acids)IBA
10/2012 - 10/2004
3malic acid (malate)IBA
01/2020 - 01/2002
3Therapeutic UsesIBA
01/2019 - 04/2004
3Sucrose (Saccharose)IBA
01/2017 - 08/2007
3Arginine (L-Arginine)FDA Link
08/2013 - 05/2003
3Glucose (Dextrose)FDA LinkGeneric
10/2012 - 02/2002
3Fatty Acids (Saturated Fatty Acids)IBA
03/2011 - 08/2006
3Galactose (Galactopyranose)FDA LinkGeneric
08/2009 - 05/2003
3Threonine (L-Threonine)FDA Link
12/2007 - 10/2005
3NAD (NADH)IBA
08/2007 - 12/2002
2SugarsIBA
01/2020 - 02/2006
2Alanine (L-Alanine)FDA Link
12/2019 - 11/2012
2Kazal Pancreatic Trypsin InhibitorIBA
04/2016 - 11/2008
2Triglycerides (Triacylglycerol)IBA
11/2012 - 02/2006
2OrnithineIBA
08/2009 - 12/2002
2Lactic Acid (Lactate)FDA LinkGeneric
08/2007 - 04/2006
2Mannitol (Osmitrol)FDA LinkGeneric
02/2006 - 03/2005
2Systemic carnitine deficiencyIBA
02/2006 - 12/2002
2Solute Carrier ProteinsIBA
12/2002 - 01/2002
1Dietary ProteinsIBA
12/2019
1Oxidoreductases (Dehydrogenase)IBA
12/2019
1Amino Acid Transport System X-AG (Glutamate Transporter)IBA
01/2019
1Codon (Codons)IBA
01/2019
1Lipid NanoparticlesIBA
01/2019
1Dietary SugarsIBA
01/2017
1Ethanol (Ethyl Alcohol)IBA
01/2017
1Transaminases (Aminotransferases)IBA
04/2016
1alpha-glycerophosphoric acid (sodium glycerophosphate)IBA
09/2015
1Complementary DNA (cDNA)IBA
01/2013
1Sodium Glutamate (Accent)IBA
11/2012
1Starch (Cornstarch)IBA
11/2012
1AlbuminsIBA
10/2012
1BilirubinIBA
10/2012
1CholesterolIBA
10/2012
1Alanine Transaminase (SGPT)IBA
10/2012
1Aspartate Aminotransferases (Aspartate Transaminase)IBA
10/2012
1pyruvate dehydrogenase kinase 4IBA
03/2011
1IronIBA
04/2010
1acyl-ghrelinIBA
11/2009
1Corticotropin-Releasing HormoneIBA
11/2009
1Phosphotransferases (Kinase)IBA
08/2009
1Carboxyl and Carbamoyl Transferases (Carbamoyltransferases)IBA
08/2009

Therapy/Procedure

6Liver Transplantation
01/2019 - 01/2002
6Therapeutics
01/2019 - 01/2002
2Oral Administration
12/2019 - 12/2011
2Carbohydrate-Restricted Diet (Low Carbohydrate Diet)
11/2010 - 05/2003
2Protein-Restricted Diet (Diet, Protein Restricted)
01/2010 - 05/2003
2High-Protein Low-Carbohydrate Diet (Atkins Diet)
03/2007 - 05/2003
1Diet Therapy (Therapy, Diet)
01/2010
1Total Parenteral Nutrition
08/2009